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Her practice is primarily concerned with creating a catalyst for discussion on our untenable existence and a sustainable future. Through her work she questions our ability to balance progress with the preservation of the environment. 

Gilmour's practice calls attention to urgent contemporary subject matter concerned with climate change, land possession, sustainable consumption and the political and environmental impact of land and sea borders. She explores landscapes that have suffered trauma in recent or deep geological time. Her work includes painting, drawing, print, photography and installation. Having spent decades within research institutions previously working as a physicist and recently as an artist in residence, Gilmour has compiled a database of facts that explore our understanding of nature. She creates installations and imagery from scientific equipment relevant to the analysis of our surroundings, artefacts of geological importance and photographic evidence of entropy at play in nature and in society. Gilmour's work is engaged in site-specific investigation, scientific and historical research. Recent work resulted from field research in the High Arctic, supported by the Arts Council of Ireland, as part of an art and science expedition in 2019.